Survival and Recovery of Apheresis Platelets Stored in a Polyolefin Container with High Oxygen Permeability a Running Short Title: High Oxygen Permeable Platelet Storage Container

Survival and recovery of apheresis platelets stored in a polyolefin container with high oxygen permeability.

BACKGROUND AND OBJECTIVES Oxygen permeability is important in platelet storage media. We compared a new polyolefin container with enhanced oxygen permeability (PO-80; Kawasumi, Tokyo, Japan) to a widely used alternative (PL2410; Baxter Healthcare, Deerfield, IL, USA). MATERIALS AND METHODS In vitro characteristics of paired platelet concentrates (PCs; mean 4.2 x 10(11)/250 ml plasma/bag) stor...

Title Survival and recovery of apheresis platelets stored in apolyolefin container with high oxygen permeability

Improved storage of platelets for transfusion in a new container.

The storage of platelet concentrates (PC) at 22#{176}Cin polyvinylchloride containers has been limited to 3 days. Even within this time interval, fall in pH to 6.0 or less with associated loss of viability occurs in a substantial number of PC. Previous work demonstrated that the fall in pH resulted from increased production of lactic acid due to hypoxic conditions within the container and could...

Seven-day storage of apheresis platelets: report of an in vitro study.

BACKGROUND The objective of this study was to determine the allowable platelet content limits for apheresis platelets stored for 7 days in a platelet storage bag (COBE ELP, Gambro BCT). METHODS Apheresis platelets under controlled concentration and volume per bag were stored in plasma up to 8 days at 22 degrees C with horizontal agitation. Routinely evaluated in vitro platelet parameters were...

کاهش سطوح بیان رسپتور پلاکتی GPIbα به‌واسطه ریزش خارج غشایی در فرآورده‌های پلاکتی تغلیظ شده از پلاسمای غنی از پلاکت

Background: Platelet adhesion typically occurs by the critical role of GPIb-V-IX in capturing free-flowing platelets to the injured vessel wall where its rapid binding kinetics enables platelet tethering even under conditions of high shear through the interaction of the major ligand-binding subunit of GPIb-V-IX, GPIbα with subendothelial-bound vWF. During storage, platelet undesired activation ...